Latest TRT & HRT News
Breaking developments in testosterone therapy, hormone replacement, FDA regulation, and clinic updates. Independent analysis with practical guidance.
Federal Men's Health Office Stalls. What It Means for TRT
The State of Men's Health Act has bipartisan support but faces political headwinds. Here's what the proposed federal office means for testosterone access.
Perimenopause and Oral Health: Gum Disease, Tooth Loss, and How HRT Helps (2026)
Estrogen receptors line your gums, jaw, and salivary glands. When levels drop in perimenopause, gum disease, dry mouth, and bone loss accelerate. Here is what to do.
Best Supplements to Take on TRT (2026)
Evidence-based supplements that actually matter on TRT: magnesium, zinc, vitamin D, omega-3s, creatine, and boron. Dosing, timing, and what to skip.
Microplastics Are Lowering Testosterone. Here's What to Do
New research confirms microplastics damage Leydig cells, cross the blood-testis barrier, and suppress testosterone. Practical steps to reduce exposure and protect your hormones.
Perimenopause Dizziness & Vertigo: Causes & HRT Guide (2026)
Over 35% of perimenopausal women experience dizziness or vertigo. Here's why estrogen decline triggers it and how HRT can restore balance.
Retatrutide Hits 30% Weight Loss in TRIUMPH-1 Trial
Eli Lilly's triple-agonist retatrutide matched bariatric surgery in Phase 3. What 28-30% weight loss means for men with obesity-related low testosterone.
Dietary Guidelines Now Cover Testosterone. What Works?
The 2025-2030 Dietary Guidelines added a testosterone section for the first time. Experts say the evidence is weak. Here's what actually moves the needle.
Still Tired on TRT? 8 Reasons and How to Fix Them (2026)
15-35% of men on TRT still feel fatigued. Here are the 8 most common causes — from estradiol imbalance to thyroid dysfunction — and how to fix each one.
Perimenopause Gut Health: Why Digestion Changes and How HRT Helps (2026)
94% of menopausal women report digestive symptoms. Here's how estrogen decline disrupts your gut, what the estrobolome is, and which HRT protocols restore normal digestion.
TRT Influencers Are Selling You a Diagnosis
A Sydney study found 72% of testosterone posts have financial ties and zero cite evidence. Here's how to spot the red flags before you get sold TRT you don't need.
New Pharma Tariffs Could Raise TRT and HRT Costs
100% tariffs on imported pharmaceutical ingredients take effect in 2026. How they affect testosterone, estrogen, and compounding pharmacy prices.
Traveling With TRT: TSA, International, Tips (2026)
How to fly with testosterone injections, pass TSA, manage time zones, and handle international rules. A practical travel guide for men on TRT.
GLP-1 Raises T Without Weight Loss: AUA 2026
AUA 2026 retrospective cohort of 1,600+ men shows GLP-1 drugs raise total and free testosterone independent of age, BMI, and weight loss.
HRT and Thyroid Medication: How Estrogen Changes Dosing (2026)
Oral estrogen raises thyroid binding globulin and can lower free T4. What women on levothyroxine need to know about HRT, retesting, and dose adjustments.
TRT Injection Pain (PIP): Causes and Prevention (2026)
Post-injection pain is the most common reason men quit TRT in the first 90 days. The actual causes, the fix sequence, and when pain means something serious.
TRT Modality Matters: AUA 2026 Cohort on Symptoms
AUA 2026 real-world cohort of 469 men shows symptom improvement on TRT differs by modality — injections, gels, and clomiphene are not equal.
Aviva AVA-291: Aromatization-Resistant Testosterone for Women
Aviva Bio's AVA-291 is a deuterium-modified testosterone designed to resist aromatization and lower breast-cancer-cell-proliferation signal by approximately 1,000-fold.
Estradiol Patch Dosing Guide for Women (2026)
Estradiol patch doses run 0.025-0.1 mg/day. Most women start at 0.05 mg. Here's how to pick, titrate, and target serum estradiol 50-100 pg/mL.
BMS 2026 Progestogen Rules: Higher Estrogen Needs More
British Menopause Society updated its progestogen guidance May 2026. Higher estrogen needs higher progesterone for endometrial protection — here's how.
DHT on TRT: When to Test It and When to Lower It (2026)
DHT rises 2-3x on TRT. Here is when the biomarker actually matters, when to test, and what to do before reaching for finasteride or dutasteride.
Compounded TRT and HRT: Where the FDA Stands Now
The FDA proposed banning compounded testosterone and bioidentical hormones. After Commissioner Makary's signal, here's where things actually stand.
Restless Legs in Menopause: Hormonal Causes & HRT Fix (2026)
Up to 15.7% of midlife women develop restless legs. Here's the estrogen-dopamine-iron link, why it spikes in perimenopause, and how HRT actually helps.
Menopause Society: No Testosterone Justification Beyond HSDD
The Menopause Society 2025 meeting said testosterone in women is justified only for HSDD, not muscle, bone, heart, mood, or fatigue. What the evidence shows.
TRT Water Retention: Why You're Bloated and How to Fix It (2026)
Why TRT causes water retention, puffy face, and bloating — plus how to tell estradiol bloat from sodium bloat and the dosing fixes that actually work.
Perimenopause Heart Risk: AHA 9,248-Woman Window Study
New AHA analysis of 9,248 women shows perimenopausal women are 2x more likely to have low cardiovascular health. What to test and when to act.
Recurrent UTIs After Menopause: Vaginal Estrogen Protocol (2026)
Postmenopausal recurrent UTIs drop 75% with vaginal estrogen. AUA 2025 guideline says start it early. Dosing, formulations, and what to expect.
TRT After 50: Dosing, Labs & Safety for Older Men (2026)
How TRT dosing, monitoring, and side-effect risk shift after 50 — slower titration, tighter hematocrit, prostate labs, and what to ask your clinic.
Perimenopause Panic Attacks: HRT Protocol Guide (2026)
Panic attacks during perimenopause are 4x more common than premenopause. Here's why estrogen swings trigger them and which HRT protocol works.
TRT Before Hip and Shoulder Surgery: New 2026 Data
Two propensity-matched 2026 studies show preoperative TRT raises infection, kidney injury, and revision rates after hip and shoulder replacement.
TRT Acne: Causes, Prevention, and Treatment Protocol (2026)
Why TRT triggers acne, who is at highest risk, and the dose, frequency, skincare, and DHT-management adjustments that clear it without quitting therapy.