Safety
25 articles tagged “Safety”
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BMS 2026 Progestogen Rules: Higher Estrogen Needs More
British Menopause Society updated its progestogen guidance May 2026. Higher estrogen needs higher progesterone for endometrial protection — here's how.
TRT Before Hip and Shoulder Surgery: New 2026 Data
Two propensity-matched 2026 studies show preoperative TRT raises infection, kidney injury, and revision rates after hip and shoulder replacement.
TRT After Prostate Cancer: SPIRIT Trial Results
A new JAMA Internal Medicine trial randomized 136 prostate cancer survivors to testosterone or placebo. Here's what 24 weeks of data showed.
Testosterone Cuts Glioblastoma Death Risk 38% in NIH Study
A May 2026 Cleveland Clinic study in Nature found men on testosterone supplements had 38% lower glioblastoma mortality. What it means for TRT users.
Testosterone Therapy CV Safety in Women: 2026 Review
Feb 2026 systematic review of 2,628 women on testosterone: zero cardiovascular deaths in trials. What the data actually says — and where the gaps are.
TRT and Bone Fractures: A New Risk Signal
A 2026 analysis links TRT to a 3-fold higher risk of shoulder fractures, echoing the TRAVERSE substudy. What it means for older men on testosterone.
Blood Test Flags Combined HRT Dementia Risk in Some
March 2026 JAMA study: high p-tau217 plus combined HRT linked to 4x dementia risk. What it means if you are on or considering hormone therapy.
HRT and Breast Cancer Risk: What WHI Got Wrong
Estrogen-only HRT cuts breast cancer mortality 40%. Combination HRT adds 1 case per 50-200 women. The real numbers behind the WHI scare.
European TRT Verdict: AFib Signal, Heart Safety
Europe's testosterone expert panel issued its 2026 TRAVERSE verdict. Heart attacks reassuring, atrial fibrillation signal real. What changes for you.
TRT, Heart Risk, and Prostate Cancer: 41-Trial Review
A new 2026 meta-analysis pooled 41 RCTs and 11,161 men. Here's what it actually says about TRT, heart attacks, strokes, and prostate cancer.
Low T Tied to Prostate Cancer Progression: 924 Men
A 2026 MD Anderson study found low testosterone raised the odds of high-grade prostate cancer progression on active surveillance by 61 percent.
9,537 Men on TRT: Real-World Safety Data
A new 2026 cohort tracked 9,537 men on TRT for up to a year. Here's what the data says about hematocrit, libido, and who runs into trouble.
TRT and Surgery Risk: What 13,000 Patients Reveal
A 2026 AAOS study of 13,000+ patients links pre-surgery TRT to higher infection, clot, and complication rates. What to tell your surgeon.
HRT Cuts Fracture Risk 24-34%: Bone Data
Women lose up to 20% of bone density in the 5-7 years after menopause. HRT cuts fracture risk 24-34%. When to start, DEXA timing, and what the data shows.
TRT and Prostate Cancer: The 80-Year Myth
The 1941 study that linked testosterone to prostate cancer was based on one patient. Here's what 80+ years of research actually shows.
TRT and Heart Risk: TRAVERSE Trial Explained
The TRAVERSE trial studied 5,246 men on TRT for cardiovascular safety. Here's what the landmark study found and why the FDA removed its heart warning.
TRT and Sleep Apnea: Risks & How to Monitor
Does TRT cause sleep apnea? The evidence is more nuanced than guidelines suggest. Learn who's at risk and how to monitor.
Protocols & Results
TRT After 50: Dosing, Labs & Safety for Older Men
How TRT dosing, monitoring, and side-effect risk shift after 50 — slower titration, tighter hematocrit, prostate labs, and what to ask your clinic.
TRT and Blood Pressure: What the Data Shows
What TRAVERSE, ambulatory BP studies, and the FDA's 2025 label change show about TRT and blood pressure — plus how disciplined clinics monitor it.
TRT Bloodwork Schedule: When to Test on TRT
The exact lab panels and timing for TRT monitoring -- from baseline through year one and beyond. Trough draws, what to skip, and when to flag results.
High Hematocrit on TRT: When to Worry & How to Fix
Hematocrit climbing on TRT? Learn the exact thresholds, 4 proven management strategies, and when elevated red blood cells actually become dangerous.
Treatment
HRT After Hysterectomy: Testosterone & Recovery
Hysterectomy with ovary removal drops testosterone 50% overnight. When to start HRT, which hormones you need, and what recovery actually looks like.
Bioidentical vs Synthetic HRT: What Matters
FDA-approved bioidenticals exist. Compounded ones skip testing. Here's what the evidence says about safety, efficacy, and cost for women's HRT.
Testosterone Side Effects in Women: Which Reverse
Most side effects stop when you stop — except two that are permanent. What's normal at each dose, frequency data, and the heart/cancer evidence.
