Topical testosterone formulations include commercially available gels (such as 1% and 1.62% preparations) and compounding pharmacy creams (typically 10-20% concentration). Both deliver testosterone through transdermal absorption, eliminating the need for injections.
Compounded testosterone cream has gained popularity in TRT circles because it produces a favorable metabolite profile. Transdermal application results in higher DHT (dihydrotestosterone) conversion compared to injections, which some practitioners believe provides additional benefits for libido, mood, and body composition. It also tends to produce less estradiol conversion than injectable testosterone.
Application is straightforward: a measured dose is applied to thin-skinned areas (typically the scrotum, inner thigh, or shoulders) once daily, usually in the morning. Scrotal application produces significantly higher DHT levels and better absorption than other sites. The cream absorbs within 15-30 minutes, after which the area can be washed or covered.
The main drawback is the transfer risk: until fully absorbed, the cream can transfer to partners, children, or pets through skin contact. Dosing consistency can also vary based on application site, skin thickness, and individual absorption rates. Lab monitoring is important to ensure adequate absorption and proper dosing.