Estradiol is the primary estrogen in men, produced mainly through aromatization of testosterone. The sensitive LC-MS/MS assay (not the standard immunoassay designed for female ranges) is essential for accurate male estradiol measurement. Estradiol is important for bone density, cardiovascular health, libido, and cognitive function.
Both too-high and too-low estradiol cause problems. Symptoms of high E2 include water retention, mood swings, and gynecomastia. Symptoms of low E2 include joint pain, fatigue, and low libido.