DHEA-S is the sulfated (storage) form of DHEA, the most abundant steroid hormone produced by the adrenal glands. DHEA-S levels decline steadily with age and serve as a marker of adrenal function. Low DHEA-S may indicate adrenal insufficiency or chronic stress.
Some TRT protocols include DHEA supplementation (25-50 mg daily) for men with documented low levels, as exogenous testosterone does not restore DHEA production.